PREVALENCE AND CORRELATES OF ALPHA-DELTA SLEEP IN MAJOR DEPRESSIVE DISORDERS by KUMARASWAMY BUDUR, MD Submitted in partial fulfillment of the requirements for the degree of Master of Science Thesis Adviser: Dr. Robert Fox

by KUMARASWAMY BUDUR, MD Objective: Major depressive disorder (MDD) is associated with sleep disturbances. An electroencephalographic (EEG) pattern of alpha wave intrusion in delta wave sleep (alpha-delta sleep) is observed in some subjects with MDD. The treatment-resistant symptoms in MDD, non-restorative sleep and fatigue, are associated with alpha-delta sleep. The objective of this study is to identify the prevalence and clinical correlates of alpha-delta sleep in MDD. Methods: Retrospective study of 150 polysomnograms of subject’s ≥ 18 years (75 each with and with no MDD). The percent of delta waves with alpha intrusion was collected and analyzed. Results: MDD patients had higher alpha-delta sleep (23.4±14.2 %; 2.3±6.7%, p<0.01). MDD patients with high alpha-delta sleep were at 3.15 greater odds to have excessive daytime sleepiness. Conclusion: Patients with MDD have a higher prevalence of alpha-delta sleep. Alpha-Delta sleep is associated with daytime sleepiness in MDDpatients.